Why lipoprotein(a) cholesterol is gaining attention as an indicator of heart health

Most people know about “good” and “bad” cholesterol. But few realise there is another type called lipoprotein(a). It can raise the risk of heart attacks and strokes, even in people who do everything right.

This lesser-known cholesterol particle, often written as Lp(a), is gaining increasing attention from researchers and drug companies.

Lp(a) isn’t included in routine cholesterol tests and there’s currently little we can do about it. That may now be changing.

What is lipoprotein(a)?

Lipoprotein(a) is a cholesterol that carries lipoprotein – particles made of fats and proteins – in your blood. It’s structurally similar to LDL (low-density lipoprotein, or “bad” cholesterol), but with an additional protein attached called apolipoprotein(a).

This extra protein component seems to make Lp(a) more likely to contribute to the build-up of fatty deposits in arteries. It may also promote blood clotting. Together, these processes increase the likelihood of cardiovascular disease (heart disease and stroke).

Large-scale studies and international guidelines now recognise Lp(a) as a risk factor for heart disease and stroke.

What determines your Lp(a) levels?

Unlike most other cholesterol measures, Lp(a) is largely determined by genetics.

Around 70%-90% of variation in Lp(a) levels is inherited. This is driven mainly by differences in the LPA gene, which controls the structure of apolipoprotein(a).

Because of this strong genetic control, Lp(a) levels are usually set early in life and remain relatively...

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