Drugs to treat Parkinson’s and restless leg syndrome can lead to risky behaviour

Getting a headache and feeling sick are common side-effects for many medicines. Indulging in risky sexual behaviour or pathological gambling – not so common.

But a BBC investigation has highlighted that some drug treatments for restless leg syndrome and Parkinson’s disease can lead to such risky behaviour.

Over 150,000 people in the UK live with Parkinson’s – a degenerative condition that affects the brain. The main part of their brain that is damaged is the area that produces dopamine, a chemical messenger that regulates movement. Less dopamine in the brain can lead to symptoms such as tremors, muscle stiffness, slow movements and problems with balance.

Another movement disorder is restless legs syndrome (RLS), which affects between 5% and 10% of people in the UK, US and Europe. Twice as many women as men have RLS among those aged over 35.

People with RLS feel they need to uncontrollably move their legs, and may experience a crawling, creeping or tingling sensation in them. Usually, the symptoms are worse at night when dopamine levels tend to be lower. Although the exact cause of RLS is unknown, it has been linked to genes, underlying health conditions, and an imbalance of dopamine.

One of the main treatments for movement disorders is a group of drugs called dopamine-receptor agonists, which include cabergoline, ropinirole,...

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