Over-the-counter (OTC) analgesics like acetaminophen, ibuprofen, and acetylsalicylic acid (aspirin) have long been a staple in households for managing pain, fevers, and other common ailments. However, the accessibility of these medications can make them easy to take in dangerous amounts. In a new study, researchers at the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children's Hospital analyzed the 549,807 calls made to Poison Control Centers (PCCs) in the US for suicide-related cases involving OTC analgesics from 2000 through 2018 and found that both the overall number and rate of these cases increased significantly by 57% and 34%, respectively, during this period. This trend was driven primarily by the increasing exposures among 6-19-year-old females.