Neonatal exposure to antigens of commensal bacteria promotes broader immune repertoire

Neonatal exposure to antigens of commensal bacteria promotes broader immune repertoire
University of Alabama at Birmingham researchers have added fresh evidence that early exposure to vaccine-, bacterial- or microbiota-derived antigens has a dramatic effect on the diversity of antibodies an adult mammal will have to fight future infections by pathogens. This antibody diversity is called the clonal repertoire—basically different single cells with distinct antibody potential that can multiply into a large clone of cells, all producing that distinct antibody.