Mouse model used to determine personalized treatment for a cancer patient

Mouse model used to determine personalized treatment for a cancer patient
A team from IDIBELL and ICO, using a mouse orthotopic model, conducted a real-time personalized oncology study to test the best therapeutic option to treat a type of relapse sarcoma. Malignant Peripheral Nerve Sheath Tumor (MPNST) are very aggressive and do not usually have a good prognosis, especially if complete surgical excision cannot be achieved. To generate the orthotopic model, a small fresh fragment of the patient's tumor was implanted on the same day of surgery in the same mouse tissue. Once the tumor had grown in the mouse, several treatments were tested and the response was analyzed.