A team of otolaryngologists and pathologists at Johns Hopkins Medicine has confirmed that SARS-CoV-2, the novel coronavirus behind the current COVID-19 pandemic, can colonize the middle ear and mastoid region of the head behind the ear. Based on this, the team recommends that physicians, surgeons, nurses and other health care professionals—especially otolaryngologists—should practice recommended protective procedures against SARS-CoV-2 when dealing with examination, sample collecting, treatment and surgery of these two connected areas.