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Gut Piezo1 regulates gut and bone homeostasis via RNA sensing

Gut Piezo1 regulates gut and bone homeostasis via RNA sensing
Gut enterochromaffin cells regulate gut and bone homeostasis via serotonin production. A recent report suggested that gut microbes regulate serotonin levels, but the underlying molecular mechanisms are unexplored. Here, Piezo1 is reported to be crucial for serotonin production from gut. Researchers discovered that bacterial derived RNA could activate Piezo1, leading to the production of serotonin from enterochromaffin cells, and that the RNA-Piezo1 axis could be an important target for treatment of bone and gut disorders.