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COVID-19: Anti-viral strategy with double effect

COVID-19: Anti-viral strategy with double effect

When the SARS-CoV-2 virus penetrates human cells, it lets the human host cell produce proteins for it. One of these viral proteins, called PLpro, is essential for the replication and rapid spread of the virus. An international team of researchers led by Goethe University, University Hospital Frankfurt and Max Planck Institute of Biophysics has now discovered that the pharmacological inhibition of this viral enzyme not only blocks virus replication but also strengthens the anti-viral immune response at the same time.