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Canakinumab shows promise for treatment of large joint osteoarthritis

An exploratory analysis of data from the CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcomes Study) randomized double-blind, placebo-controlled trial found that patients receiving interleukin-1β (IL-1β) inhibitors had significantly lower rates of total hip or total knee replacements over an average follow up of 3.7 years. These findings are important, as no treatments currently exist that can either prevent or slow progression of osteoarthritis. The study is published in Annals of Internal Medicine.